Manchester United will be hoping to use the home field to their advantage when they welcome Atletico Madrid to Old Trafford in their last 16 return leg on Tuesday.
Manchester United will head into this fixture full of confidence after Cristiano Ronaldo netted a hat-trick in the win over Spurs on Saturday.
The win leaves United on 50 points in fifth place after 29 games, one behind Arsenal, who have two games in hand.
Atletico Madrid come into this game looking to extend their unbeaten run after Brazilian defender Renan Lodi scored two goals in their convincing 2-0 home win over Celta Vigo.
The win sees Atletico in fourth place in the La Liga standings.
The Spaniards are in fine form across all competitions with four wins in the league going with their draw against United.
In the last five meetings between the two teams, Atletico has come out on top having secured three wins, while United have only won one game and with their most recent game ending in a draw.
Atletico Madrid manager Diego Simeone: “After the group stage is over, you can win the Champions League only with draws.
“We have to repeat many things from today’s game. There are many positive things, it may look as if they have the advantage but nothing changed. It’s like it all will begin from scratch in Old Trafford.”
Manchester United manager Ralf Rangnick: “Atletico had problems with this approach. We have to show this in other positions as well, one or two other players, in every single position. If we want to go through we have to play like that.
“We have to have more energy. It’s not about game plans or tactics. It’s about conviction. It’s about belief. This is not enough. This is the Champions League.”
Anthony Elanga has been a super-sub for United over the past two weeks after he came off the bench to score against Leeds United and Atletico, but he will be roaring for a place in the starting lineup to add to his goal tally of three goals.
Renan Lodi comes into this match the man in form for Atletico after he fired his side to victory with a brace against Celta Vigo over the weekend.
The Red Devils will have two players sidelined for the game with Scott McTominay out from illness while Edinson Cavani has recovered from a groin strain, while Atleti will be without captain Koke, who has a muscle injury, Daniel Wass with a ligament injury and Matheus Cunha out with a knee injury.
Possible Starting Lineup:
Manchester United: David De Gea, Victor Lindelöf, Alex Telles, Raphael Varane, Aaron Wan-Bissaka, Fred, Anthony Elanga, Bruno Fernandes, Paul Pogba, Nemanja Matic, Cristiano Ronaldo.
Atletico Madrid: Jan Oblak, Jose Gimenez, Reinildo, Stefan Savic, Renan Lodi, Hector Herrera, Sime Vrsaljko, Geoffrey Kondogbia, Marcos Llorente, João Félix, Angel Correa.