Manchester United will West Ham in the fifth round of the FA Cup following the Hammers 2-0 win over Derby on Monday.
National League Wrexham – owned by Hollywood actor Ryan Reynolds – are still in line to face a potentially huge tie against Tottenham Hotspur.
The fifth round fixtures taking place between February 26 and January 2.
Manchester City, meanwhile, will travel to Championship opposition in Bristol City, a side they defeated over two legs in the Carabao Cup semi-final in 2018.
But the major talking point of the draw belongs to fifth-tier Wrexham, who could face Antonio Conte’s Tottenham if they defeat Sheffield United in a replay at Bramall Lane.
That match takes place on February 7.
Draw for the English FA Cup fifth round made on Monday:
Southampton vs Luton or Grimsby
Leicester vs Blackburn or Birmingham
Stoke vs Brighton
Wrexham or Sheffield United vs Tottenham
Fulham or Sunderland vs Leeds
Bristol City vs Manchester City
Manchester United vs Derby or West Ham
Ipswich or Burnley vs Sheffield Wednesday or Fleetwood
Ties will be played during the week commencing February 27.