Roma will need to score at least four goals if they are to upset Manchester United and advance to the Europa League finals.
The Italians will be managed by former Red Devils mentor Jose Mourinho next season although the team that “The Special One” left behind at Old Trafford is a vastly different unit to the one that will start on Thursday.
This current United side might very well be the best squad since Sir Alex Ferguson left the dugout.
Manchester United have no fresh injury concerns with a weekend break following Sunday’s postponed outing against Liverpool.
The home side will be without Pau Lopez after the goalkeeper was forced off during the 6-2 loss to United.
Goalkeeper Pau Lopez misses out after dislocating his shoulder at Old Trafford with Daniel Furzato and Antonio Mirante competing for the gloves.
Roma lost at the weekend to Sampdoria in league action with Leonardo Spinazzola, Jordan Veretout and Amadou Diawara all missing.
There is some good news with Gianluca Mancini fit again. Former United duo Chris Smalling and Henrikh Mkhitaryan will be fighting for starting places.
It seems highly unlikely that Roma will spoil United’s quest to make the final.
The visitors have not lost away in this competition and have lost just once in 22 games across all competitions. Real Sociedad, AC Milan and Granada were all beaten away without conceding. Couple that with Roma’s poor form and a place in the final is all but secured even with 90 minutes to play.